Types of ketamine therapy
There are two types of ketamine therapy used to treat major depression in those patients who haven’t
responded to two or more antidepressant medications. The first is administered intravenously. Ketamine IV infusion
is the most common and most effective type of ketamine therapy. Most of the research conducted
has been on the ketamine IV infusion method. A secondary method is delivered via nasal spray.
Ketamine IV infusion for sale
Racemic ketamine, which is administered intravenously, goes directly to the patient’s bloodstream. This is called
intravenous, or IV, ketamine. The treatment is a mix of two mirror-image molecules, which are called “R” and “S” ketamine.
The FDA approved its use decades ago for use as an anesthetic. For patients with treatment-resistant depression, doctors are
using it off-label. IV ketamine infusion therapy is not a first-line treatment for depression. Rather, it’s administered when
antidepressant medications fail. Administered through an IV infusion in the arm, ketamine takes effect right away, and the effects
can last from days to weeks. Patients typically receive a series of six infusions over two to three weeks as part of an “induction” phase.
After that, the maintenance period begins, and patients typically return for one infusion every two to six weeks.
Esketamine (Spravato) is administered as a nasal spray. It uses only the “S” molecule rather than the combination of
both R and S. This form of ketamine treatment is FDA approved; however, there is far less research on its
effectiveness in treating depression. The two forms of ketamine interact differently with brain receptors,
and the delivery method (IV versus nasal spray) also affects the drug’s effectiveness as well as side effects. Much more
research is needed to compare the efficacy of esketamine (Spravato).
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